Sponsored by

University of Pittsburgh School of Medicine

Center for Continuing Education in the Health Sciences

and the

Department of Critical Care Medicine




International Conference on Complexity in Acute Illness


November 7 - 9, 2004


Conference Room S100, Biomedical Science Tower

University of Pittsburgh

200 Lothrop Street, Pittsburgh, PA





Session I: Modeling Approaches to Acute Inflammation

9:30 a.m.           Introductory Remarks                                                       Gilles Clermont/Edmund Neugebauer

9:45 a.m.           Understanding the Illness Caused by Injury                        Timothy R. Billiar

10:15 a.m.          Multiple Organ Dysfunction from an Epithelial                   Russ Delude

                         Cell's Prospective                             

10:45 a.m.         COFFEE BREAK                                                                             

11:00 a.m.         Discrete Dynamical Simulations                                        G. Bard Ermentrout

11:30 a.m.         Simulation Modeling                                                          Mark S. Roberts

12:00 p.m.         LUNCH                                                                         Room S123BST


Session II: Methodological and Statistical Issues in Modeling Complex Systems

1:00 p.m.           Optimal Allocation of Observaions in Models                      Gregory M. Constantine

                         Defined by Dynamical Systems

1:30 p.m.           Predicting Outcome in Trauma Victims                              Rolf Lefering

2:00 p.m.           A Signal Processing Approach to Classifying Mass             Milos Hauskrecht

                         Spectrometry Data                                                         

2:30 p.m.           COFFEE BREAK

2:45 p.m.           Validation and Calibration in Animals of a                          Yoram Vodovotz

                        Mathematical Model of Inflammation

3:15 p.m.           Optimization Issues in Modeling                                         John Bartels

3:45 p.m.           Challenges of Global Optimization Algorithms                     Andrew Schaefer

4:15 p.m.           Panel Discussion






Session III: Organ Function and Dysfunction

8:30 a.m.           Theories of MODS                                                          Michael Pinsky

9:00 a.m.           Modeling in the Study of Irreversible Shock States             Juan Puyana

9:30 a.m.           Biologic Variability and Organ Function                             Andrew Seely

10:00 a.m.         Biomedical Signal Changes in Acute Traumatic                  Brahm Goldstein

                        Brain Injury

10:30 a.m.         COFFEE BREAK

10:45 a.m.         Cardiac Output Variations:  Modeling Controller                 Adam Seiver


11:15 a.m.         Continuous Hemofiltration: A Salutary Intervention             John A. Kellum

                        in Acute Biological Stress?

11:45 a.m.         Criteria for Inclusion of Variables in Models of Acute         Edmund Neugebauer

                        Inflammation of Relevance to Trauma and Sepsis

12:15 p.m.         LUNCH                                                                         Room S123 BST


Session IV: Young Investigators Seminars

12:30 p.m.         Poster Viewing and Discussion Session                                    BST Lobby

1:30 p.m.           A simple model of nosocomial infection in the lung               Krzystof Laudanski (Rochester, NY)

1:50 p.m.           Alterations in antigen presentation by macrophages              Steward Chang (Ann Arbor, MI)

                         during infection with M. Tuberculosis                                     

2:10 p.m.           Cooperativity in apoptosome formation might be important    Elife Z Bagci (Pittsburgh, PA)

                        for the appropriate response of cell to apoptotic stimulus

2:30 p.m.           Heart rate variability, approximate entropy, and exponent      Vasiliios Papaioannou (Thessanoliki, Greece)

            .           analysis of HR signals of patients a multidisciplinary  ICU 

2:50 p.m.           A reduced model of the immune response to endotoxin:        Judy Day (Pittsburgh, PA)

                         a geometric approach

3:10 p.m.           An explanation for the existence and variable severity          Daniel Frattarell (Detroit, MI)

                         of adverse drug reactions          

3:30 p.m.           On the role of the macrophage biochemical network during  Christian Ray (Ann Arbor, MI)

                         infection with M. Tuberculosis

3:50 p.m.           Interaction of hemodynamics and fluid balance between       Sven Zenker (NorthRhine Westfalia, Germany)

                        intravascular and interstitial compartments in septic shock  

4:10 p.m.           BioLogic: mathematical modeling of complex systems          Rima Gandlin (Pittsburgh, PA)

4:30 p.m.           Simulating changes in variability and complexity during         Anton Burykin (Los Angeles, CA)

                        multiple organ dysfunction: a model of coupled stochastic


4:50 p.m.           Dynamics of HIV-1 infection in the lymph node during          Seema Bajaria (Ann Arbor, MI)

5:10 p.m.           Blood pressure variability in a murine model of sepsis            Steven Hollenberg (Camden NJ)

5:50 p.m.           ADJOURNMENT

7:00 p.m.           Presenters and Chairpersons Dinner






Session V: Specific Models of Complex Biomedical Systems

9:00 a.m.           Dynamics of a Granulomatous Response                           Denise Kirschner

                         by M. tuberculosis                                                                               

9:30 a.m.           Modeling the Logic of Intra-Cellular Signaling                    Shlomo Ta’asan

10:00 a.m.         Modular Concepts of Multi-Scale, Multi-Tissue Modeling    Gary An

                        of Acute Inflammation

10:30 a.m.         COFFEE BREAK

10:45 a.m.         A Nephrologist’s Menagerie of Complex Systems              John R. Hotchkiss

11:15 a.m.         Bacterial Surface Carbohydrates and Host Survival in        John G. Younger

                        a Biodistributive Model of Gram-Negative Bacteremia

11:45 a.m.         In Silico Clinical Trial Design: Lessons and Directions        Gilles Clermont

12:15 p.m.         LUNCH                                                                         Room S123BST


Session VI: Academia and Industry

1:00 p.m.           Entrepreneurial Development of Discoveries Made            Mitchell P. Fink

                         in an Academic Setting: Lessons Learned

1:30 p.m.           Complexity and Industry: An Unlikely Marriage?                Thomas Petzinger

2:00 p.m.           The Marketplace of Diseases Associated with                   Steven Chang

                        Acute Inflammation

2:30 p.m.           COFFEE BREAK

2:45 p.m.           Mathematical Models in the Pharmaceutical Industry          Billy W. Day

3:15 p.m.           Data Mining of Complex Datasets                                     Frederick D. Busche

3:45 p.m.           New Optimization Techniques                                           James Kraemer

4:15 p.m.           The Biotech Marketplace – Reality Check 2004                 Reed McManigle

4:45 p.m.           Panel Discussion

5:15 p.m.           ADJOURNMENT





Faculty Disclosure:  In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials distributed at the time of the conference.


Special Needs:  Participation by all individuals is encouraged. Advance notification of any special needs will help us provide better service. Please notify us of your needs at least two weeks in advance of the program by calling Donna Kruse at 412-647-7980.