Publications and Links on Complex Systems / Systems Biology in Acute Illness

 Neugebauer E, Rixen D, Raum M, Schafer U. Thirty years of anti-mediator treatment in sepsis and septic shock--what have we learned?(PubMed Link)
 Kirschner, D. Dynamics of co-infection with M. Tuberculosis and HIV-1. (PubMed Link)
Seely AJ, Christou NV. Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems. (PubMed Link)
Buchman TG, Cobb JP, Lapedes AS, Kepler TB. Complex systems analysis: a tool for shock research. (PubMed Link)
Neugebauer EA, Willy C, Sauerland S. Complexity and non-linearity in shock research: reductionism or synthesis? (PubMed Link)
Wigginton J.E., Kirschner, D. A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis. (PubMed Link)
Ellenby, M. S., McNames, J., Lai, S., McDonald, B. A., Krieger, D., Sclabassi, R. J., Goldstein B. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. (PubMed Link)
Hlavacek, W. S., Redondo, A., Metzger, H., Wofsy, C., Goldstein, B. Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. (PubMed Link)
Tjardes T, Neugebauer E. Sepsis research in the next millennium: concentrate on the software rather than the hardware. (PubMed Link)
An, G. Agent-based computer simulation and SIRS: building a bridge between basic science and clinical trials. (PubMed Link)
Buchman, T.G. The community of the self. (PubMed Link)
Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, Barrette TR, Shankar-Sinha S, Sarma VJ, Padgaonkar, VA, Ward PA. Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation. (PubMed Link)
Cobb JP, Laramie JM, Stormo GD, Morrissey JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, Hotchkiss RS. Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. (PubMed Link)
Ellenby MS, McNames J, Lai S, McDonald BA, Krieger D, Sclabassi RJ, Goldstein B. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. (PubMed Link)
Cameron RJ, Sleigh JW. Chaotic sepsis and the magic bullet. (PubMed Link)
Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. (PubMed Link)
Goldstein, B., McNames, J., McDonald, B. A., Ellenby, M., Lai, S., Sun, Z., Krieger, D., Sclabassi, R. J. Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit. (PubMed Link)
Neugebauer E, Tjardes T and the Multidisciplinary Working Group on Complexity, New Approaches to Shock and Trauma Research: Learning from Multidisciplinary Exchange (PubMed Link)
Goldstein B., Faeder J.R., Hlavacek W.S. Mathematical and computational models of immune-receptor signalling. (PubMed Link)
Kumar R, Clermont, G, Vodovotz, Y, Chow CC. The dynamics of acute inflammation. J.Theoretical Biol. 2004. (PubMed Link)
An, G. In-silico experiments of existing and hypothetical cytokine-directed clinical trials using agent based modeling. Crit Care Med. 2004. (PubMed Link)
Vodovotz Y., Clermont G., Chow C., An G. Mathematical models of the acute inflammatory response. Curr.Opin.Crit Care 2004.(PubMed Link)
Clermont, G., Chow, C. C., Constantine, G. M., Vodovotz, Y., Bartels, J. Mathematical and Statistical Modeling of Acute Inflammation. Proc.Internatl.Fed.Classific.Soc. 2004.(In Press)
Vodovotz, Y., Chow, C. C., Bartels, J., Lagoa, C., Kumar, R., Day, J., Rubin, J., Constantine, G., Billiar, T. R., Fink, M. P., Clermont, G. In silico models of acute inflammation in animals. Shock 2004.(In Press)
Vodovotz, Y., Kim, P., Bagci, E. Z., Ermentrout, G. B., Chow, C. C., Bahar, I., Billiar T. R.. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Curr.Mol.Med. 2004.(PubMed Link)
Clermont, G., Bartels, J., Kumar, R.; Constantine, G., Vodovotz, Y., Chow, C. In silico design of clinical trials: a method coming of age. Crit Care Med. 2004.(PubMed Link)