Publications on Complex Systems / Sys. Biology in Acute Illness

Vodovotz, Y.; Clermont, G.; Hunt, C.A.; Lefering, R.; Bartels, J.; Seydel, R.; Hotchkiss, J.; Ta’asan, S.; Neugebauer, E.;  An, G. Evidence-based modeling of critical illness: An initial consensus from the Society for Complexity in Acute Illness. J. Crit. Care. 2007. 22:77-84.

An, G.; Hunt, C.A.; Clermont, G.; Neugebauer, E.; Vodovotz, Y. Challenges and rewards on the road to translational systems biology in acute illness: Four case reports from interdisciplinary teams. J. Crit. Care. 2007. 22:169-175. [PubMed Link]

Dick, T.E.; Molkov, Y.I.; Nieman, G.; Hsieh, Y-H.; Jacono, F.J.; Doyle, J.; Scheff, J.; Calvano, S.E.; Androulakis, I.; An, G.; Vodovotz, Y. Linking inflammation, cardiorespiratory variability, and neural control in acute inflammation via computational modeling. Frontiers in Comp. Physiol. and Medicine. 2012. 3:222. [Pubmed Link]

Scheff, J.D.; Mavroudis, P.D.; Foteinou, P.T.; An, G.; Calvano, S.E.; Doyle, J.; Dick, T.E.; Lowry, S.F.; Vodovotz, Y.; Androulakis, I.P. A multiscale modeling approach to inflammation: A case study in human endotoxemia. J. Computational Physics. 2013. 244:279-289. [DOI Link]

Vodovotz, Y.; An, G.; Androulakis, I.P. A systems engineering perspective on homeostasis and disease. Frontiers Bioengineering Biotechnol. 2013. 1 (Article 6): 1-8. [Pubmed Link]

Aerts, J-M.; Haddad, W.; An, G.; Vodovotz, Y. From data patterns to mechanistic models in acute illness. J. Crit. Care. 2014. 29:604-610. [Pubmed Link]

Day, J.; Cockrell, C.; Namas, R.; Zamora, R.; An, G.; Vodovotz, Y. Inflammation and disease: Modelling and modulation of the inflammatory response to alleviate critical illness. Curr. Opin. Syst. Biol. *Co-senior authors. Curr. Opin. Syst. Biol. 2018. 12:22–29. [Pubmed Link]

An, G and Day, J. 2019. Precision Systems Medicine: A Control Discovery Problem. Reference Module in Biomedical Sciences. Elsevier. ISBN 9780128012383. [DOI Link]

Vodovotz, Y; Xia, A; Read, E; Bassaganya-Riera, J;  Hafler, D.A; Sontag, E.; Wang, J; Tsang, J.S; Day, J; Kleinstein, S; Butte, A.J; Altman, M.C.; Hammond, R; and Sealfon. S.C. 2017. Solving Immunology? Trends in Immunology. 38(2):116-127. doi: 10.1016/ [Pubmed Link]

Day, J; Metes, D. M.; Vodovotz, Y. 2015. Mathematical modeling of early cellular innate and adaptive immune responses to ischemia/reperfusion injury and solid organ allotransplantation. Frontiers in Immunology. Alloimmunity and Transplantation. 6:1-19. doi:10.3389/fimmu.2015.00484 [Pubmed Link]

Day, J., Rubin, J., Clermont, G., 2010. Using nonlinear model predictive control to find optimal therapeutic strategies to modulate inflammation. Math. Biosci. Eng. 7(4):739-763. doi:10.3934/mbe.2010.7.739 [Pubmed Link]